Bernardo Silva and Arda Guler also scored at the Bernabeu.
Real Madrid beat RB Leipzig 4-1 at the Santiago Bernabeu in the Champions League league phase on Wednesday.
Bernardo Silva and Arda Guler scored either side of half-time to put Madrid in control. Kylian Mbappe made it 3-0 in the 83rd minute, and Yan Diomande volleyed in a fourth.
Tidiam Gomis scored Leipzig's consolation goal.
The win keeps Madrid among the front-runners in the league phase, with attention now turning to the El Clasico against Barcelona this weekend.
