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Microsoft AI system diagnoses complex cases step by step, outperforms doctors in study

24 October 2026

The tool was more than twice as accurate as physicians on over 300 difficult cases.

Microsoft researchers have developed an AI system that diagnoses patients step by step, deciding which questions to ask and which tests to order, much like a doctor working through a case.

In a study published in Science, the system was more than twice as accurate as general physicians on over 300 unusual and complex cases, and also beat doctors on emergency room scenarios.

An orchestrator coordinates the process using a simulated panel of clinical experts, and its diagnostic workups cost less than those designed by human doctors.

Microsoft will now work with a Boston hospital to test whether the tool can help triage patients in emergency department waiting rooms.

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